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伯豪生物
伯豪生物 | 時空組學研究整體解決方案
發布時間:2019-12-11 瀏覽次數:567210
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伯豪生物園區

伯豪生物協助客戶發表文章數據

伯豪生物榮獲:“10X Genomics  中國單細胞及空間組學優選服務商”

10X 單細胞空間轉錄組優質服務商


科研技術服務平臺多樣       滿足不同樣本實驗需求

單細胞組學研究解決方案、單細胞多組學 =

▲伯豪生物(部分)技術平臺展示


序號 提供服務 技術平臺 應用方向 服務樣本保障
單細胞核 RNA 測序
【科研服務】
10X Genomics ★冰凍組織。
★FFPE 樣本。
  • 應用方向同 單細胞 RNA 測序;
  • 核測序無法獲得胞漿基因表達。
伯優?
伯豪生物獨研
細胞核分離試劑盒
單細胞 RNA 測序
【科研服務】

1、高通量平臺:
10X Genomics;
BD Rhapsody;
2、低通量平臺:
SMART-seq 2。
★腫瘤異質;
★腫瘤免疫微環境;
★胚胎發育;
★細胞分化。
(受細胞活率,懸液單胞率等影響)。
  伯優?
伯豪生物獨研
單細胞樣本保存液
無懼異地時效影響
單細胞 ATAC 測序
【科研服務】

10X Genomics
★腫瘤異質性;
★免疫微環境;
★神經科學;
★胚胎發育;
★細胞分化等領域的研究。
單細胞 TCR/BCR 測序
(單細胞免疫組庫測序)
【科研服務】

10X Genomics
BD Rhapsody
10X genomics 提供了全面的單細胞免疫分析方案;
通過精簡的工作流程,可以實現從樣品到文庫準備、
免疫測序和軟件分析全套解決方案,
揭示 T 和 B 細胞多樣性、
V(D)J 重組和免疫細胞分析。
單細胞 ATAC+RNA 測序
(單細胞多組學聯合)
【科研服務】

10X Genomics
★干細胞;
★免疫;
★癌癥;
★神經科學。
伯優?
伯豪生物獨研
單細胞樣本保存液
無懼異地時效影響
單細胞全長轉錄本測序
【科研服務】

Nanopore 
★發現不同細胞攜帶的突變,攜帶突變的細胞與非突變
細胞相比,挖掘基因表達規律。

★挖掘基因功能(如膜蛋白、分泌蛋白、轉錄因子等
編碼基因轉錄本使用情況,并發現全新功能的轉錄本)。

★發現融合基因所在的細胞亞群,研究它們與腫瘤細胞
的擬時序分化關系。

★發現亞群特異性的全新 lncRNA。

★獲得亞群特異性表達的轉錄本,能夠輔助小核酸類藥
物開發企業等。
伯優?
伯豪生物獨研
單細胞樣本保存液
無懼異地時效影響
空間轉錄組測序
【科研服務】

10X Genomics Visium
★空間位置信息,或者細胞在組織中天然的狀態。
★腫瘤學;
★免疫學;
★發育生物學;
★神經科學;
★病理學等方向。
伯優?
伯豪生物獨研
單細胞樣本保存液
無懼異地時效影響
FFPE 空間轉錄組測序
【科研服務】

10X Genomics Visium
★空間位置信息,或者細胞在組織中天然的狀態。
★腫瘤學;
★免疫學;
★發育生物學;
★神經科學;
★病理學等方向。
-


科研服務儀器平臺任選

伯豪生物
10X Genomics 儀器平臺
1660178981339 1660179026625
儀器平臺名稱 Chromium Controller Chromium X
原理 Next GEM Next GEM
單次運行樣本數 8 16
捕獲細胞數 500-10,000 2,000-20,000
捕獲效率 65% 65%
雙細胞率 0.8% per 1000 cells 0.4% per 1000 cells
兼容性 不兼容新試劑 兼容舊試劑

科研服務儀器平臺任選

研究成果

序號 協助客戶發表文章 雜志 IF 日期 樣本類型
1 Characterization of Cancer Stem Cells 1 in Laryngea Squamous Cell Carcinoma by Single-cell RNA Sequencing Genomics, Proteomics & Bioinformatics 11.5 2024 Sep 6 人喉癌組織
2 Disrupting YAP1-mediated glutamine metabolism induces synthetic lethality alongside ODC1 inhibition in osteosarcoma CELLULAR ONCOLOGY 4.9 2024 Aug 08 人細胞
3 RAC1 inhibition ameliorates IBSP-induced bone metastasis in lung adenocarcinoma Cell Reports 7.5 2024 Jul 24 人肺癌骨轉移
4
Single-cell RNA-seq reveals abnormal differentiation of keratinocytes and increased inflammatory differentiated keratinocytes in atopic dermatitis
Journal of the European Academy of Dermatology and Venereology 9.2 2023 Nov 人皮膚
5 Abnormal metabolism in melanocytes participates in the activation of dendritic cell in halo nevus CLINICAL IMMUNOLOGY 8.6 2024 Jun 29 人暈痣
6
Activation of CD14+ Monocytes via the IFN-γ Signaling Pathway Is Associated with Immune-Related Adverse Events in Hepatocellular Carcinoma Patients Receiving PD-1 Inhibition Combination Therapy
biomedicines 3.9 2024 May 21 人外周血
7 Distinct roles of TREM2 in central nervous system cancers and peripheral cancers Cancer Cell 50.3 2024 May 23 小鼠腦膠質瘤
8
Calcified apoptotic vesicles from PROCR+ fibroblasts initiate heterotopic ossification
J Extracell Vesicles 16 2024 Apr 大鼠肌腱
9 Landscape of gut mucosal immune cells showed gap of follicular or memory B cells into plasma cells in immunological non-responders Clinical and Translational Medicine 10.6 2024 May 23 人 Ileocyte 粘膜組織樣本
10 Dissecting microenvironment in cystadenomas and hepatic cysts based on single nucleus RNA-sequencing data COMPUTERS IN BIOLOGY AND MEDICINE 7.7 2024 May 03 人肝囊腫
11 Mapping cell diversity in human sporadic cerebral cavernous malformations GENE 3.5 2024 May 22 人石蠟樣本
12 An advanced comprehensive muti-cell-type-specific model for predicting anti-PD-1 therapeutic effect in melanoma Theranostics 12.4 2024 Mar 03 人骨軟組織
13 Heat shock protein gp96 drives natural killer cell maturation and anti-tumor immunity by counteracting Trim28 to stabilize Eomes Nature Communications 16.6 2024 Feb 06  小鼠脾細胞
14 Deciphering the heterogeneity of neutrophil cells within circulation and the lung cancer microenvironment pre- and post-operation CELL BIOLOGY AND TOXICOLOGY 6.1 2024 Feb 06  人組織 / 血液
15
Mrc1+ macrophage-derived IGF1 mitigates crystal nephropathy by promoting renal tubule cell proliferation via the AKT/Rb signaling pathway
Theranostics 12.4 2024 Feb 17 小鼠腎組織
16 Radiotherapy-Induced Astrocyte Senescence Promotes anImmunosuppressive Microenvironment in Glioblastoma to Facilitate Tumor Regrowth Advanced Science 15.1 2024 Feb 11 小鼠大腦組織
17 Single-cell transcriptomic analyses of tumor microenvironment and molecular reprograming landscape of metastatic laryngeal squamous cell carcinoma
Communications Biology 5.9 2024 Jan 08 喉癌組織
18
Behind the Indolent Facade: Uncovering the Molecular Features and Malignancy Potential in Lung Minimally Invasive Adenocarcinoma by Single-Cell Transcriptomics
Advanced Science 15.1 2023 Nov 22 人肺癌組織
19 Single-cell and spatial heterogeneity landscapes of mature epicardial cells Journal of Pharmaceutical Analysis 8.8 2023 Jul 22 小鼠心臟
20
FOXG1 drives transcriptomic networks to specify principal neuron subtypes during the development of the medial pallium
DEVELOPMENTAL NEUROSCIENCE 13.116 2023 Mar 10 小鼠腦
21
Single cell RNA-seq analysis identifies ferroptotic chondrocyte cluster and reveals TRPV1 as an antiferroptotic target in osteoarthritis
EBioMedicine 5.736 2022 Sep 19 人軟骨
22
Microtubule stabilization targeting regenerative chondrocyte cluster for cartilage regeneration
Theranostics 8.579 2023 Jun 12 人軟骨
23
Single-Cell Sequencing Informs That Mesenchymal Stem Cell Alleviates Renal Injury Through Regulating Kidney Regional Immunity in Lupus Nephritis
STEM CELLS AND DEVELOPMENT 4 2023 Aug 8 小鼠腎臟
24 The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity Cell Metabolism 29 2023 Aug 04 結直腸癌組織
25 Role and Therapeutic Potential for Targeting Fibroblast Growth Factor  10/FGFR1 in Relapsed Rheumatoid Arthritis Arthritis and Rheumatology 13.3 2023 Aug 16 人滑膜組織
26 A single-cell transcriptional landscape of immune cells shows disease-specific changes of T cell and macrophage populations in human achalasia Nature Communications 16.6 2023 Aug 04 人食管下括約肌 & 血液
27 Single-cell RNA sequencingreveals the Muller subtypes andinner blood-retinal barrierregulatory network in earlydiabetic retinopathy Frontiers in Molecular Neuroscience 6.261 2022 Dec 01 人視網膜
28
Single-Nucleus Transcriptome Profiling of Locally Advanced Cervical Squamous Cell Cancer Identifies Neural-Like Progenitor Program Associated with the Efficacy of Radiotherapy
Advanced Science 15.1 2023 Jul 09 人宮頸腫瘤
29 Updated skin transcriptomic atlas depicted by reciprocal contribution of single-nucleus RNA sequencing and single-cell RNA sequencing JOURNAL OF DERMATOLOGICAL SCIENCE 4.6 2023 Jun 20 人皮膚
30 SCUBE2 mediates bone metastasis of luminal breast cancer by modulating immune-suppressive osteoblastic niches CELL RESEARCH 46.297 2023 May 04 小鼠腿骨
31 The role of signaling crosstalk of microglia in hippocampus on progression of ageing and Alzheimer’s disease Journal of Pharmaceutical Analysis 14.026 2023 May 15 小鼠海馬
32 General anesthetic action profile on the human prefrontal cortex cells through comprehensive single-cell RNA-seq analysis iScience 6.107 2023 Apr 21 人大腦前額葉皮質組織
33
Single-cell RNA sequencing highlights intratumor heterogeneity and intercellular network featured in adamantinomatous craniopharyngioma
SCIENCE ADVANCES 14.957 2023 April 12  人顱咽管瘤
34
Tumor microenvironment remodeling after neoadjuvant immunotherapy in non?small cell lung cancer revealed by single?cell RNA sequencing
Genome Medicine 15.266 2023 Mar 03 人血液 / 肺癌組織
35 Identification of a tumour immune barrier in the HCC microenvironment that determines the efficacy of immunotherapy Journal of Hepatology  30.083 2023 Jan 25 人肝臟
36
Single-cell RNA sequencing combined with single-cell proteomics
identifies the metabolic adaptation of islet cell subpopulations
to high-fat diet in mice
Diabetologia 10.46 2023 Jan 小鼠胰腺
37 Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell migration to restrain infection and autoimmunity Cell Reports 9.995 2023 Jan 18 小鼠細胞
38
Single-cell RNA-sequencing uncovers compound kushen injection synergistically improves the efficacy of chemotherapy by
modulating the tumor environment of breast cancer
Frontiers in Immunology 8.786 2022 Oct 30 小鼠乳腺(癌)組織
39 A YAP/TAZ-CD54 axis is required for CXCR2 ?CD44 ? tumor-specific neutrophils to suppress gastric cancer Protein & Cell 15.328 2022 Oct 26 人小鼠血液
40
Single-cell dissection of remodeled inflammatory
ecosystem in primary and metastatic gallbladder
carcinoma
Cell Discovery 38.079 2022 Oct 05 人膽囊組織
41 Defining Specific Cell States of MPTP-Induced Parkinson’s Disease by Single-Nucleus RNA Sequencing INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 6.208 2022 Sep 15 小鼠腦
42
Single‐cell transcriptome atlas reveals protective
characteristics of COVID‐19 mRNA vaccine
Journal of Medical Virology 20.693 2022 Sep 19 人肺組織
43
Tumor-polarized GPX3+ AT2 lung epithelial cells promote
premetastatic niche formation
PNAS 12.779 2022 Jul  小鼠肺組織
44 Single-Cell RNA Sequencing of Peripheral Blood Mononuclear Cells From Acute Myocardial Infarction frontiers in immunology 8.786 2022 Jun 29 人外周血
45 Brain single-nucleus transcriptomics highlights that polystyrene nanoplastics potentially induce Parkinson’s Disease-like neurodegeneration by causing energy metabolism disorders in mice Journal Of Hazardous Materials 14.224 2022 Feb 11 小鼠腦組織
46
Patient-derived organoids for personalized gallbladder
cancer modelling and drug screening
Clinical and Translational Medicine 8.554 2022 Jan 人膽囊組織
47 Anatlas of dynamic peripheral blood mononuclear cell landscapes in human perioperativeanaesthesia/surgery Clinical and Translational Medicine 8.554 2022 Jan 人外周血
48 Single-nucleus transcriptomic atlas of spinal cord neuron in human Elife 6.4 2021 Sep 30 人腦組織
49
Single-cell RNA Sequencing Technology Revealed
the Pivotal Role of Fibroblast Heterogeneity in Ang
II-Induced Abdominal Aortic Aneurysms
DNA AND CELL BIOLOGY 3.55 2021 Nov 小鼠腎上腹主動脈
50 iNKT subsets differ in their developmental and functional requirements on Foxo1 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 12.779 2021 Nov 16 小鼠骨髓
51 Inherent hepatocytic heterogeneity determines expression and retention of edited F9 alleles post-AAV/CRISPR infusion PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 12.779 2022 Oct 小鼠肝組織
52 Single-cell profiling of tumor-infiltrating TCF1/TCF7 + T cells reveals a T lymphocyte subset associated with tertiary lymphoid structures/organs and a superior prognosis in oral cancer ORAL ONCOLOGY 5.972 2021 May 25 人口腔組織
53 A novel recombinant cccDNA-based mouse model with long term maintenance of rcccDNA and antigenemia Antiviral Res 10.103 2020 Aug 小鼠肝組織
54
In vivo simultaneous transcriptional activation of
multiple genes in the brain using CRISPR–dCas9-
activator transgenic mice
Nature Neuroscience 28.771 2018 Mar 小鼠腦組織
55 Single-cell transcriptomics reveals the landscape of intra-tumoral heterogeneity and transcriptional activities of ECs in CC Molecular Therapy-Nucleic Acids 10.183 2021 Apr 2 人宮頸癌組織
56 A TNFR2-hnRNPK axis promotes primary liver cancer development via activation of YAP signaling in hepatic progenitor cells Cancer Res  13.312 2021 Feb 22 人肝組織
57
Characterization of the heterogeneity of endothelial cells
in bleomycin?induced lung fibrosis using single?cell RNA sequencing
Angiogenesis 10.658 2021 May 小鼠肺組織
58 Single-cell transcriptomic analysis of somatosensory neurons uncovers temporal development of neuropathic pain Cell Research 46.297 2021 Mar 10 小鼠腓腸神經
59 Liver type 1 innate lymphoid cells develop locally via an interferon-g–dependent loop Science 63.714 2021 Mar 26 小鼠肝臟細胞
60 Single-cell transcriptome atlas of lung adenocarcinoma featured with ground glass nodules  Cell Discovery 38.079 2020 人肺癌組織
61 Somatosensory neuron types identified by high-coverage single-cell RNA sequencing and functional heterogeneity Cell Res 46.297 2015 小鼠背根神經節


為什么要選擇伯豪生物?

1、伯豪生物按客戶需求真實開展實驗,不辜負每一位客戶的傾心托付。

2、伯豪生物已通過 ISO9001:2015 國際質量標準認證,實驗項目服務有保障。

3、伯豪生物實驗團隊項目經驗豐富,從樣本到數據,實驗質量有保障。

4、至今,風雨兼程 15 載,伯豪生物與科研工作者共同攜手,累計發布 SCI 論文 2500 余篇。平均影響因子大于 7.2 分。

……



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